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59 although the difference did not reach statistical significance, the weight gain was lower for fluoxetine 1 but higher for citalopram, fluvoxamine and paroxetine 2.

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Bupropion can be taken along with paroxetine 9 , but this combination should be used with caution and dosage reduction may be needed.

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The prescribing information states that paroxetine should not be used in combination with an maoi including linezolid, an antibiotic which is a reversible non-selective maoi , or within 14 days of discontinuing treatment with an maoi , and should not be used in combination with pimozide, thioridazine, tryptophan, or warfarin.

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Patients should be cautioned about the risk of serotonin syndrome with the concomitant use of paroxetine hydrochloride controlled-release tablets and triptans, tramadol, or other serotonergic agents.

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When a single oral 30-mg dose of immediate-release paroxetine was administered at phenobarbital steady state 100 mg once daily for 14 days , paroxetine auc and t were reduced by an average of 25 and 38 , respectively compared to paroxetine administered alone.

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